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The doctor replies that the illness is quite serious but can be cured by inserting a suppository up his anal passage. 

The man agrees, and so the doctor warns him of the pain, tells him to bend over and shoves the thing way up his behind. 

The doctor then hands him a second dose and tells him to do the same thing in six hours.

So, the man goes home and later that evening tries to get the second suppository inserted, but he finds that he cannot reach himself properly to obtain the required depth. 

He calls his wife over and tells her what to do.  The wife nods, puts one hand on his shoulder to steady him and with the other shoves the medicine home. 

Suddenly the man screams, "DAMN!"   "What's the matter?" asked the wife, "Did I hurt you?"

"No," replies the man, "but I just realized that when the doctor did that, he had BOTH hands on my shoulder."